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The mismatch between our biology and the modern world

Our brains are essentially running on an ancient paradigm in a world that has been completely redesigned.  The fundamental architecture of the human brain hasn't dramatically changed in roughly 200,000 years. We still have the same neural circuitry that helped our ancestors survive on the African savanna.  That brain was adapted for a world rife with immediate  threats, tightly knit social groups, nomadic life, and direct contact with raw nature. 

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